THIN GLOMERULAR
BASEMENT MEMBRANE DISEASE (TMBD)
Diagnosis
TMBD must be differentiated from the other two common causes of glomerular hematuria, IgA nephropathy, and Alports syndrome. History and presentation are helpful in this regard. A Kidney Biopsy is the only way to diagnose thin basement membrane disease. It reveals thinning of the glomerular basement membrane from the normal 300 to 400 nanometers (nm) to 150 to 250 nm. A biopsy is rarely done in patient who present with only hematuria with normal kidney function and no proteinuria. The prognosis is excellent for TMBD but may co-exist with other kidney diseases.
TMBD must be differentiated from the other two common causes of glomerular hematuria, IgA nephropathy, and Alports syndrome. History and presentation are helpful in this regard. A Kidney Biopsy is the only way to diagnose thin basement membrane disease. It reveals thinning of the glomerular basement membrane from the normal 300 to 400 nanometers (nm) to 150 to 250 nm. A biopsy is rarely done in patient who present with only hematuria with normal kidney function and no proteinuria. The prognosis is excellent for TMBD but may co-exist with other kidney diseases.
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